POTENSI SENYAWA EUGENOL DARI CENGKEH (Syzygium aromaticum) SEBAGAI INHIBITOR PROTEASE HIV-1 (PR)

Antioxidant properties of flavonoids

Flavonoids, metabolit sekunder terbanyak yang bersumber dari tanaman, telah lama dimanfaatkan sebagai obat tradisional dan secara ilmiah juga telah terbukti memiliki efek farmakologi. Senyawa ini juga memiliki beragam manfaat terhadap kesehatan sehingga sangat berpotensi sebagai bahan baku untuk pengembangan obat baru. Penelitian terbaru memaparkan pemanfaatan flavonoids sebagai antioksidan unt...

HIV-1 protease mutations and protease inhibitor cross-resistance.

The effects of many protease inhibitor (PI)-selected mutations on the susceptibility to individual PIs are unknown. We analyzed in vitro susceptibility test results on 2,725 HIV-1 protease isolates. More than 2,400 isolates had been tested for susceptibility to fosamprenavir, indinavir, nelfinavir, and saquinavir; 2,130 isolates had been tested for susceptibility to lopinavir; 1,644 isolates ha...

Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation

BACKGROUND Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosterol and ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetam...

HIV Protease Inhibitor : Past

Effect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor

Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...